Medically reviewed by our clinical team · Last reviewed Oct 19, 2026 · How we create and review content
What is semaglutide?
Semaglutide is a GLP-1 receptor agonist. It mimics a natural gut hormone that helps regulate appetite, slows stomach emptying and improves blood sugar control. The FDA approved semaglutide 2.4 mg (Wegovy) for chronic weight management in June 2021, according to the FDA approval package. Wegovy is used together with a reduced-calorie diet and more physical activity. A lower-dose version (Ozempic) is approved for type 2 diabetes.
Who qualifies for semaglutide for weight loss?
Under the FDA-approved labeling, Wegovy is indicated for adults with:
- A BMI of 30 or higher, or
- A BMI of 27 or higher with at least one weight-related condition, such as high blood pressure, type 2 diabetes or high cholesterol
Labeling has expanded since 2021, including a cardiovascular risk-reduction indication for certain adults with heart disease. Your clinician will review current labeling against your history.
Who should not take semaglutide
- Anyone with a personal or family history of medullary thyroid carcinoma or MEN 2 syndrome (semaglutide carries a boxed warning about thyroid C-cell tumors)
- Anyone with a prior serious allergic reaction to semaglutide
- People who are pregnant or planning pregnancy
- Extra caution with a history of pancreatitis, gallbladder disease, diabetic retinopathy or kidney problems
Side effects to know about
The most common side effects are gastrointestinal: nausea, vomiting, diarrhea, constipation and abdominal pain. They're usually worst during dose increases, which is why the dose is raised gradually over several months. Serious risks listed in the labeling include pancreatitis, gallbladder problems, low blood sugar when combined with some diabetes medicines, and kidney injury from dehydration.
Compounded and unapproved semaglutide
The FDA has warned consumers about unapproved GLP-1 drugs used for weight loss, including dosing errors and products sold as "research" chemicals or salt forms. Once the FDA declared the semaglutide shortage resolved, the rules for compounded copies tightened. TRT Houston clinicians will tell you which options are legitimate and available at the time of your visit.
How the program works
- Online intake: weight history, medical conditions, medications and goals.
- Baseline labs: typically a metabolic panel and A1C, with lipids or thyroid tests as needed, drawn at a Houston-area lab.
- Video visit: eligibility review, a risks-and-benefits discussion, and a plan.
- Gradual dose escalation with regular check-ins about side effects.
- Ongoing support: nutrition, protein intake, strength training and sleep, which help preserve muscle while you lose fat.
Weight, testosterone and men's health
Excess weight and low testosterone are closely linked in men. Losing weight can raise testosterone in some men, and low testosterone can make weight loss harder. If symptoms of low T are part of your story, your clinician may also evaluate testosterone replacement therapy or a broader hormone panel.
Semaglutide weight loss in Houston, supervised
Houston's food scene is one of the best in the country, which doesn't make weight management easier. A GLP-1 can be a powerful tool when you're eligible, it's prescribed properly, and it's monitored. Start with an online consult or call (281) 670-9727.
Semaglutide Weight Loss in Houston: FAQs
How much weight do people lose on semaglutide?
Results vary widely. In the trials that led to approval, average weight loss was substantially greater than placebo when the drug was combined with diet and activity, but individual results differ. Your clinician will discuss realistic expectations.
Is semaglutide covered by insurance?
Coverage depends on your plan and diagnosis. Ask about insurance and HSA/FSA options during your consult. Pricing is shared after your initial consult.
What happens if I stop semaglutide?
Many people regain weight after stopping. Your clinician will talk about long-term planning before you start.
Can I take semaglutide while on TRT?
Some men use both under supervision. Your clinician will review interactions, labs and goals.
Do I need labs before starting?
Usually, yes. Baseline labs help confirm eligibility and safety. They can be drawn at a Quest or Labcorp near you.